What's wrong with Bonferroni adjustments

What's wrong with Bonferroni adjustments.

False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies.

OBJECTIVES Procedures for controlling the false positive rate when performing many hypothesis tests are commonplace in health and medical studies. Such procedures, most notably the Bonferroni adjustment, suffer from the problem that error rate control cannot be localized to individual tests, and that these procedures do not distinguish between exploratory and/or data-driven testing vs. hypothes...

Whats and whys with neonatal CT.

What and why? As health care professionals, we must address both of these questions in scientific inquiry as well as in clinical practice. Most times, facts (the “what”) are relatively easy to come by. The reasons (the “why”) behind these events are usually more difficult to discover and understand. Let us look at the example of head computed tomography (CT) in a group of neonates. There are 2 ...

Rapid Survey of Wasting and Stunting in Children: Whats New, Whats Old and Whats the Buzz?

Nationwide Rapid Survey on Children (RSoC), conducted by the Ministry of Women and Child Development and UNICEF in 2013-14 showed a marked improvement in the status of the child malnutrition over the third National Family Health Survey (NFHS-3) that was conducted in 2005-06. Despite some impressive gains in the anthropometric indicators of malnutrition, the absolute levels remain high, and of c...

Bonferroni - based gatekeeping procedure with retesting option

In complex clinical trials, multiple research objectives are often grouped into sets of objectives based on their inherent hierarchical relationships. Consequently, the hypotheses formulated to address these objectives are grouped into ordered families of hypotheses and thus to be tested in a pre-defined sequence. In this paper, we introduce a novel Bonferroni based multiple testing procedure f...